• Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli 

      Podnecky, Nicole L.; Aarag, Elizabeth; Kloos, Julia Maria; Sørum, Vidar; Primicerio, Raul; Roberts, Adam Paul; Rozen, Daniel E.; Samuelsen, Ørjan; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-10)
      There is urgent need to develop novel treatment strategies to reduce antimicrobial resistance. Collateral sensitivity (CS), where resistance to one antimicrobial increases susceptibility to other drugs, might enable selection against resistance during treatment. However, the success of this approach would depend on the conservation of CS networks across genetically diverse bacterial strains. Here, ...